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Nutrition: Calcium
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The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
In this study, we examined the role of TRPML1 (TRP cation channel, mucolipin subfamily, member 1) in regulating the homeostasis of secretory lysosomes and their cross-talk with mitochondria in human NK cells. We found that genetic deletion of TRPML1, which localizes to lysosomes in NK cells, led to mitochondrial fragmentation with evidence of collapsed mitochondrial cristae. Consequently, TRPML1-/- NK92 (NK92ML1-/-) displayed loss of mitochondrial membrane potential, increased reactive oxygen species stress, reduced ATP production, and compromised respiratory capacity. Using sensitive organelle-specific probes, we observed...
Source: Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Dennis Clement Edina K Szabo Silje Zandstra Krokeide Merete Thune Wiiger Marianna Vincenti Daniel Palacios Young-Tae Chang Christian Grimm Sandip Patel Harald Stenmark Andreas Brech Rakesh Kumar Majhi Karl-Johan Malmberg Source Type: research
Low-density lipoprotein subclasses over the menopausal transition and risk of coronary calcification and carotid atherosclerosis: the SWAN Heart and HDL ancillary studies
CONCLUSIONS: During the MT, women experience significant increases in LDL subclasses found to be related to greater cIMT levels and CAC prevalence. Whether these changes could better predict future risk of hard cardiovascular disease events beyond LDL-C remains a research question to address.PMID:37738035 | DOI:10.1097/GME.0000000000002245
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Samar R El Khoudary Xirun Chen Ziyuan Wang Maria M Brooks Trevor Orchard Sybil Crawford Imke Janssen Susan A Everson-Rose Daniel McConnell Karen Matthews Source Type: research
Acute spinal cord infarction secondary to ankylosing spondylitis: a case report and literature review
ConclusionAlthough this is a rare entity, it is necessary for physicians to consider it when evaluating patients with a sudden loss of sensation and strength in their lower limbs.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research
Lifestyle factors, serum parameters, metabolic comorbidities, and the risk of kidney stones: a Mendelian randomization study
ConclusionThis study provides MR evidence supporting causal associations of many modifiable risk factors with kidney stones. Sedentary lifestyles, obesity, smoking, and T2DM are mediating factors in the causal relationship between educational attainment and kidney stones. Our results suggest more attention should be paid to these modifiable factors to prevent kidney stones.
Source: Frontiers in Endocrinology - September 22, 2023 Category: Endocrinology Source Type: research
Serum basic fibroblast growth factor and interleukin-1 β predict the effect of first-line chemotherapy in patients with advanced gastric cancer
CONCLUSION: The FLOT regimen was effective in reducing the serum CEA, CA199, and TPS levels as well as in improving the 1-year survival rate of patients with good tolerability, making it worthy of clinical promotion and application.PMID:37731570 | PMC:PMC10507556 | DOI:10.12998/wjcc.v11.i26.6083
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Li Zheng Li-Hong Gan Ling Yao Bin Li Ya-Qin Huang Fu-Bao Zhang Meng-Qi Kuang Nian Fang Source Type: research
The regulation of RGLG2-VWA by Ca < sup > 2+ < /sup > ions
Biochim Biophys Acta Proteins Proteom. 2023 Sep 19:140966. doi: 10.1016/j.bbapap.2023.140966. Online ahead of print.ABSTRACTRGLG2, an E3 ubiquitin ligase in Arabidopsis thaliana, affects hormone signaling and participates in drought regulation. Here, we determined two crystal structures of RGLG2 VWA domain, representing two conformations, open and closed, respectively. The two structures reveal that Ca2+ ions are allosteric regulators of RGLG2-VWA, which adopts open state when NCBS1(Novel Calcium ions Binding Site 1) binds Ca2+ ions and switches to closed state after Ca2+ ions are removed. This mechanism of allosteric regu...
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Mei-Ling Zhang Jia-Xiang Zhang Yan Liang Shi-Cheng Tian Shu-Yang Xie Tong Zhou Qin Wang Source Type: research
CALB1: A novel antiviral factor in chicken ileal mucus
In conclusion, we isolated and identified CALB1 from chicken intestinal mucus, which suppressed replication of avian viruses by regulating cellular calcium-ion homeostasis and autophagy.PMID:37734520 | DOI:10.1016/j.ijbiomac.2023.127007
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Danqing Lu Yang Wu Mei Fu Yaotang Wu Zhisheng Wang Jian Lin Qian Yang Source Type: research
Inflammation, mitochondrial dysfunction and physical performance: a possible association in older patients with persistent atrial fibrillation-the results of a preliminary study
CONCLUSIONS: In older AF patients, IL-6 correlated with acylcarnitines and lower physical performance. Alterations in energy production, reduced physical function and inflammation could contribute to frailty development.PMID:37733227 | DOI:10.1007/s40520-023-02558-w
Source: Aging Clinical and Experimental Research - September 21, 2023 Category: Geriatrics Authors: Stefano Fumagalli Giulia Ricciardi Claudia Di Serio Giancarlo La Marca Giuseppe Pieraccini Riccardo Franci Montorzi Emanuele Santamaria Giulia Spanalatte Francesca Marchetti Ginevra Corti Laura Pinton Niccol ò Marchionni Source Type: research
Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
CONCLUSIONS: These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.PMID:37732466 | DOI:10.1161/CIRCULATIONAHA.122.061736
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Yu-Che Cheng Marvin L Hsieh Chen-Ju Lin Cindy M C Chang Ching-Ying Huang Riley Puntney Amy Wu Moy Chien-Yu Ting Darien Zhing Herr Chan Martin W Nicholson Po-Ju Lin Hung-Chih Chen Gina C Kim Jianhua Zhang Jennifer Coonen Puja Basu Heather A Simmons Yen-Wen Source Type: research
Existing Nongated CT Coronary Calcium Predicts Operative Risk in Patients Undergoing Noncardiac Surgeries (ENCORES)
CONCLUSIONS: Prevalence and severity of coronary calcium obtained from existing nongated chest CT imaging improve preoperative clinical risk stratification before nongated surgery.PMID:37732454 | DOI:10.1161/CIRCULATIONAHA.123.064398
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Daniel Y Choi Dena Hayes Samuel D Maidman Nehal Dhaduk Jill E Jacobs Anna Shmukler Jeffrey S Berger Germaine Cuff David Rehe Mitchell Lee Robert Donnino Nathaniel R Smilowitz Source Type: research
A CAMK2B variant associated with tetralogy of Fallot, developmental delay, and growth retardation
Eur J Med Genet. 2023 Sep 19:104845. doi: 10.1016/j.ejmg.2023.104845. Online ahead of print.ABSTRACTCAMK2B encodes the beta-subunit of calcium/calmodulin-dependent protein kinase II (CAMKII), which is expressed mainly in the brain. Variants of CAMK2A and CAMK2B cause neurodevelopmental disorders, and CAMK2B alterations have been described in at least 14 patients with intellectual disability and developmental delay. Here, we describe a novel CAMK2B variant in a patient with tetralogy of Fallot (TOF), developmental delay, and growth retardation. The patient was a 2-year-old female. She was delivered at 36 weeks 6 days gestat...
Source: European Journal of Medical Genetics - September 21, 2023 Category: Genetics & Stem Cells Authors: Yuji Horii Yukiko Kuroda Yoko Saito Yumi Enomoto Takuya Naruto Kenji Kurosawa Source Type: research
3D phantom for image quality assessment of mammography systems
Phys Med Biol. 2023 Sep 21. doi: 10.1088/1361-6560/acfc10. Online ahead of print.ABSTRACTOBJECTIVE: To present an innovative approach for the design of a 3D mammographic phantom for medical equipment quality assessment, estimation of the glandular tissue percentage in the patient's breast, and emulation of microcalcification ($\mu$C) breast lesions.APPROACH: Contrast-to noise ratio (CNR) measurements, as well as spatial resolution and intensity-to-glandularity calibrations under mammography conditions were performed to assess the effectiveness of the phantom. CNR measurements were applied to different groups of calcium hyd...
Source: Physics in Medicine and Biology - September 21, 2023 Category: Physics Authors: Jes ús David Bermúdez Sánchez Gerardo Alfonso Roque Juan Sebasti án Calderón García Paula Andrea Pardo Ramos Manuel Fernando S ánchez Alarcón Victor Alfonso Ramos Correa Carlos Arturo Ávila Bernal Source Type: research
Preventive effects of 13 different drugs on colorectal cancer: a network meta-analysis
CONCLUSIONS: The preventive effect of allopurinol on CRC was better than that of the other 13 drugs. These results can help doctors and patients understand the preventative effects of these drugs more intuitively and provide an evidence-based basis for the clinical application of these drugs.PMID:37732038 | PMC:PMC10507769 | DOI:10.5114/aoms/167480
Source: Archives of Medical Science - September 21, 2023 Category: General Medicine Authors: Qi Fu Huini Liao Zhihao Li Xing Chen Xuan Zhang Ji Di Source Type: research
Involvement of PI3K/Akt/ β-catenin signaling in schisandrin B-mitigated bone deterioration in an experimental rat model of estrogen deficiency
CONCLUSIONS: SchB exerted anti-osteoporotic activity in OVX-operated rats by accelerating the phosphorylation of PI3K and Akt, subsequently upregulating the expression of β-catenin.PMID:37732059 | PMC:PMC10507775 | DOI:10.5114/aoms.2020.92873
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Yimin Liang Wei Li Xiang Li Jun Nan Source Type: research
Preventive effects of 13 different drugs on colorectal cancer: a network meta-analysis
CONCLUSIONS: The preventive effect of allopurinol on CRC was better than that of the other 13 drugs. These results can help doctors and patients understand the preventative effects of these drugs more intuitively and provide an evidence-based basis for the clinical application of these drugs.PMID:37732038 | PMC:PMC10507769 | DOI:10.5114/aoms/167480
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Qi Fu Huini Liao Zhihao Li Xing Chen Xuan Zhang Ji Di Source Type: research
